Researchers at Northwestern Medicine and Brigham and Women’s Hospital claim they have found a “molecular defect” that causes lupus. Today we will discuss about Northwestern lupus Best doctors in Chicago: Hospitals,Specialist.
Northwestern lupus Best doctors in Chicago: Hospitals,Specialist
Scientists at Northwestern Medicine and Brigham and Women’s Hospital discovered the cause of lupus and its potential cure, according to a study published Wednesday. “We have identified a fundamental imbalance in the immune responses of lupus patients, and we have defined specific mediators that correct this imbalance to reduce the pathological autoimmune response,” said Dr. Deepak Rao, one of the study’s authors. can fix.” Northwestern Medicine News Center.
According to the Lupus Foundation of America, an estimated 5 million people globally have lupus, including 1.5 million in the US. “Up to this point, all therapy for lupus has been a blunt instrument. This is widespread immunosuppression,” said co-author Jaehyuk Choi. “By identifying the cause of this disease, we have found a potential cure that will not have the side effects of current treatments.”
According to Choi, Northwestern researchers are trying to identify those cells. They were able to target the genes that cause lupus and potentially reverse the disease. Lupus is an autoimmune disease that weakens the body’s ability to fight infection.
Rep. Lauren Boebert (R-CO) got a speeding ticket earlier this year after being caught going 84 mph in a 65 mph zone — but court documents obtained by Denver Alt-Weekly According to the , failed to pay the $174.50 ticket on time. Westward.
He was originally pulled over on Interstate 70 near Vail Pass on the morning of Mother’s Day, the publication reports. She was driving a black Mazda CX-50.
According to a court clerk who spoke to Westword, the right-wing firebrand finally paid the ticket earlier this month when she learned she was scheduled to appear in court.
“Tickets that are not paid to the state by the twenty day deadline will be referred to court,” the clerk said. “His case was sent to court, we opened a case, and he took a standard plea offer.”
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Scientists have identified it as possibly being the primary cause of lupus, a chronic autoimmune disease.
Researchers at Northwestern Medicine in Chicago and Brigham and Women’s Hospital in Boston claim they have found a “molecular defect” that leads to systemic lupus erythematosus (better known as lupus).
Study author Deepak Rao, M.D., Ph.D., assistant professor of medicine at Harvard Medical School and rheumatologist at Brigham and Women’s Hospital, told Fox News, “Lupus is an autoimmune disease at its core due to abnormal B cell activation and antibody production. is included.” Digitally via email.
“This B cell activation and antibody production requires help from T cells (white blood cells that are integral to immune system activity).”
During the research, scientists tested the blood of 19 lupus patients and compared it with a control group of healthy individuals.
According to Rao, certain molecular changes occurred in people with lupus that caused a “dramatic imbalance” in the types of T-cells they produced.
This imbalance results in too many “harmful” T-cells – those that cause cellular damage – and too few of the “helper” type that are needed for cell repair.
The researchers also identified a protein called interferon that promotes additional accumulation of T cells, Rao said.
Northwestern lupus Best doctors in Chicago: Hospitals,Specialist
“We have known for many years that interferon production is overexpressed in lupus patients, yet how interferon contributes to the disease has been unclear,” he said.
The study showed that interferon contributes to lupus disease by promoting the expansion of certain types of T cells and “enhancing pathological T cell-B cell interactions,” Rao said.
The researchers also discovered that activation of a specific protein, the aryl hydrocarbon receptor (AhR), can prevent T cells from developing into disease-causing cells.
“This study reveals a new potential therapeutic strategy for treating lupus,” Rao said.
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The main mystery behind one of the most common autoimmune diseases may finally be answered.
Researchers at Northwestern Medicine and Brigham and Women’s Hospital say they have discovered the root cause of lupus, a disease that affects hundreds of thousands of people in the US.
Scientists have long suspected that a person’s genetics or hormones may predispose them to lupus, and that the disease may be triggered by environmental factors such as a previous viral infection or exposure to certain chemicals.
Now, a study published Wednesday in the journal Nature outlines a clearer path for how the disease is likely to develop, pointing to abnormalities in the immune systems of people with lupus.
“We found that there is this fundamental imbalance in the types of T cells that are made in lupus patients,” said Dr. Deepak Rao, one of the study’s authors and a rheumatologist at Brigham and Women’s Hospital in Massachusetts. T-cells are white blood cells that play an important role in the body’s immune response.
The study reached its conclusions by comparing blood samples from 19 people suffering from lupus with blood samples from healthy individuals. The comparison showed that healthy cells in people with lupus had too many of a particular T cell associated with damage and too few of another T cell associated with repair.
At the heart of this imbalance lies a protein called interferon, which helps protect the body from pathogens. Scientists have known for years that people with lupus have higher amounts of type I interferon — but the new study links the issue to a number of negative effects.
First, too much type I interferon can block a protein called aryl hydrocarbon receptor, which helps regulate the body’s response to bacteria or environmental pollutants.
Blocking this receptor hinders the production of T cells that can help heal wounds on the skin, lungs, and intestinal barrier. It also stimulates the production of T cells involved in making autoantibodies.
