A new study into the underlying mechanisms of lupus potentially offers a new way to treat the autoimmune disease. Today we will discuss about lupus root cause reddit: cause identified,11 symptoms,lupus in females.
lupus root cause reddit: cause identified,11 symptoms,lupus in females
The researchers worked backwards, following the chain of events in the immune system and identified insufficient activity of a receptor in T cells, a protein called aryl hydrocarbon, as a possible root cause of the disease.
Researchers say they have discovered the root cause of lupus, a disease that affects hundreds of thousands of people in the US.
Scientists have discovered a molecular defect that promotes a pathological immune response in systemic lupus erythematosus, better known as lupus, according to Northwestern Medicine.
A study published in the journal Nature suggests that reversing this defect could potentially reverse the disease.
Medical experts say that the causes of the disease were not clear until this new study. Lupus can result in life-threatening damage to many organs, including the kidneys, brain, and heart.
“Up to this point, all therapy for lupus has been a blunt instrument. It’s widespread immunosuppression,” Jaehyuk Choi, a medical doctor and Northwestern Medicine dermatologist, said. “By identifying the cause of this disease, we have found a potential cure that will not have the side effects of current treatments.”
The study explains how lupus develops, pointing to abnormalities in the immune systems of people with the disease.
“We have identified a fundamental imbalance in the immune responses exerted by lupus patients, and we have defined specific mediators that can correct this imbalance to reduce the pathological autoimmune response,” said Deepak Rao, a said the medical doctor and assistant professor of medicine at Harvard Medical School.
The researchers shared that the study reached its conclusions by comparing blood samples from patients with lupus to blood samples from people without the autoimmune disease.
The comparison reportedly showed that people with lupus have much higher amounts of a special T cell, called T peripheral helper cells, which promote the production of disease-causing autoantibodies.
cause identified
The main mystery behind one of the most common autoimmune diseases may finally be answered.
Researchers at Northwestern Medicine and Brigham and Women’s Hospital say they have discovered the root cause of lupus, a disease that affects hundreds of thousands of people in the US.
Scientists have long suspected that a person’s genetics or hormones may predispose them to lupus, and that the disease may be triggered by environmental factors such as a past viral infection or exposure to certain chemicals.
Now, a study published Wednesday in the journal Nature outlines a clearer path for how the disease is likely to develop, pointing to abnormalities in the immune systems of people with lupus.
lupus root cause reddit: cause identified,11 symptoms,lupus in females
“We found that there is this fundamental imbalance in the types of T cells that are made in lupus patients,” said Dr. Deepak Rao, one of the study’s authors and a rheumatologist at Brigham and Women’s Hospital in Massachusetts. T-cells are white blood cells that play an important role in the body’s immune response.
The study reached its conclusions by comparing blood samples from 19 people with lupus with blood samples from healthy individuals. The comparison showed that healthy cells in people with lupus had too many of a particular T cell associated with damage and too few of another T cell associated with repair.
At the heart of this imbalance lies a protein called interferon, which helps protect the body from pathogens. Scientists have known for years that people with lupus have higher amounts of type I interferon — but the new study links the issue to a number of negative effects.
11 symptoms
First, too much type I interferon can block a protein called aryl hydrocarbon receptor, which helps regulate the body’s response to bacteria or environmental pollutants.
Blocking this receptor hinders the production of T cells that can help heal wounds on the skin, lungs, and intestinal barrier. It also stimulates the production of T cells involved in making autoantibodies, which attack healthy cells and are the hallmark of lupus.
Rao said the theory could explain most cases of lupus.
“I think this will apply to essentially all patients with lupus,” he said.
“This is very exciting research and very promising, but I think it’s too early to say that this is the root cause of the disease,” said Mara Lennard Richard, scientific program officer at the Lupus Research Alliance. The alliance is a private funder of lupus research and has contributed grant funding to Rao’s study.
Because the symptoms of lupus are so diverse and the contributing factors are manifold, “it is very difficult to find a root cause for the disease,” said Lennard Richard. “Obviously, if it causes lupus, that would be amazing and really fantastic for people with lupus.”
Dr. Jill Byne, director of the rheumatology department and Lupus Center at NYU Langone Health, said the theory will need to be tested in a larger sample of people.
“How will we know until they prospectively study 100 patients?” said Bayan, who was not involved in the study.
The Centers for Disease Control and Prevention estimates that the U.S. More than 200,000 people in the U.S. have lupus, although the Lupus Foundation of America estimates the number to be much higher: about 1.5 million people. About 90% of people with lupus are women.
Common symptoms include extreme fatigue, joint pain, or skin rashes. In rare cases, the disease can cause kidney or heart damage, or weaken the immune system so that the body cannot fight infection. These issues are fatal or life threatening
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The new study points to the possibility of better treatments in the future, which could come in the form of infusions or pills, said Dr. Jaehyuk Choi, a dermatologist at Northwestern Medicine and one of the study’s authors.
The study found that giving people with lupus anifrolumab, a drug that blocks interferon, prevented the T-cell imbalance that potentially causes the disease.
Choi said, “We followed patients who received this drug as part of their clinical care and showed that in patients who received the drug, this cell imbalance was reversed or appeared to be reversed.” Was on the way.”
In blood samples from people with lupus, the researchers also tested the effects of adding a small molecule that activates the aryl hydrocarbon receptor. They found that this limited the accumulation of disease-promoting T cells.
According to Choi, the major challenge in developing a new treatment is finding ways to administer it without activating aryl hydrocarbon receptors throughout the body, which could result in more side effects.
Even if such a treatment becomes available, Bayan said, it is unlikely to work for everyone with lupus.
He said, “We have deeply understood that one medicine will not cure everything.”
